add share buttonsSoftshare button powered by web designing, website development company in India

All About ErbB2 Antibody

ErbB2 is a type I membrane glycoprotein that belongs to the ErbB family of tyrosine kinase receptors. It is also known as Neu and human epidermal growth receptors. You can know more about Anti-ErbB 2/ERBB2 Antibody Picoband online.

ErbB2/Her2 Antibody (NB100-1710): Novus Biologicals

Image Source: Google

Members of the ErbB family operate as receptors for the epidermal growth factor (EGF) family of growth factors. ErbB2 is often found in epithelial cells and is over-expressed in the vast majority of breast tumors. In the group of ErbB relatives, ErbB2 is unique in that it does not have any identified ligands. 

Since ErbB3 has a deficient Kinase domain and kinase domain, ErbB2 is responsible for initiating the tyrosine phosphorylation signal via this heterodimeric signal. It has been discovered that a distinct 3-Acid signal inside the ErbB3 cell membrane is essential for the transactivation of ErbB2. 

The cell-cell cytoplasmic domain of ErbB2 has been demonstrated to be associated with beta-catenin as well as plakoglobin. Human ErbB2 is composed of 1255 amino acids (aa) with an aa signal sequence of 21 with a 631 aa intracellular domain, a 23-aa transmembrane area, and the cytoplasmic domain is 580 aa. 

ErbB2 can be eliminated off the cell's surface via proteolytic cleavage through an unidentified protease. ErbB2 is believed to play a role in the development of cancer and neuromuscular junction and in the control of differentiation and cell growth.